When Is Reds Opening Day 2025. The cincinnati reds will play the san francisco giants on march 27, 2025, at great american ball park on opening day in cincinnati. The cincinnati reds will once again host the first series of the season at great american ballpark as they will take on the san fransisco giants on march.
Cincinnati reds 2025 promotional schedule The 2025 reds opening day lineup will depend greatly on who’s is stepping onto the mound for the san francisco giants on march 27th.